Structure and Dynamics of Intrinsically Disordered Proteins

报告人:Prof. Wenwei Zheng (Arizona State University, USA)
报告题目:Structure and Dynamics of Intrinsically Disordered Proteins

时间:2018年06月21日(星期四) 上午10:00 

The importance of disorder in protein structure and function is becoming increasingly evident.  However the computational model able to quantitatively capture the structure and dynamics of the intrinsically disordered proteins (IDPs) is still challenging due to the very broad distribution of protein conformations.  We are actively developing computational models for IDPs in multiple resolutions, including all-atom, coarse-grained and polymer models.  In this talk I will present our coarse-grained models to investigate how IDPs undergo liquid-liquid phase separation and form dynamic assemblies.  These assemblies behave like liquid droplets and are closely related to the formation of membraneless organelles and pathological aggregates.  Our main effort has been directed toward understanding the molecular mechanisms of the phase behavior and how we can predict the phase boundaries from the composing IDP sequences.  Here we find that many of these sequences follow the properties of homopolymers.  We are therefore able to predict the phase behavior of IDP sequences using only single-molecular properties and highly-efficient single-chain simulations.

报告人简介:郑文伟博士,复旦大学2005年本科毕业,2013年获Rice大学博士学位,2014-2017年在美国国立卫生研究院(NIH)做博士后研究,2017年起任Arizona州立大学Assistant Professor. 从事理论与计算生物物理研究。在无序蛋白相分离、生物大分子力场发展与分子动力学采样算法、蛋白质折叠等方面做出了多项重要成果。