代表性工作：

1.  针对生物分子组装体中微观结构、分子相互作用与宏观物理性质之间对应关系问题，发展了微纳尺度组装体力学、电学性质的测试与调控方法，系统揭示了分子堆积方式、氢键网络、手性结构及取代基调控对力学、电学和压电性能的影响规律，拓展了生物分子组装体的性质调控策略与功能应用空间（Angew. Chem. 2025,e202500334; Nat Commun 2026, https://doi.org/10.1038/s41467-026-71043-5;  Adv. Sci. 2023, 10(11), 2207269;Small, 2023, 2309493;JACS 2022, 144 (40), 18375-18386; Mater. Today 2021, 42, 29-40）。

2.   针对水凝胶等软物质材料中宏观稳定性与微观动态性难以兼顾的问题，提出了从分子尺度精准调控宏观软材料力学性能的设计思路。通过将生物分子组装体引入水凝胶网络作为功能化力学单元，构建多尺度层级结构，实现了能量耗散、快速回复、抗疲劳、动态响应和结构稳定性等性能的协同提升，设计并开发了一系列具有特殊力学性能的生物基软材料（Adv. Mater. 2026, e23636; Nat. Commun. 2025, 16, 3637; Nat. Commun. 2024, 15, 4895; Nat. Commun. 2023, 14, 2583； Angew. Chem. 2021, 61, e202201765; Sci. Adv. 2020, 6, eaaz9531; Adv. Funct. Mater.2016, 8(24), 15120-15127）。

3.   针对生物软材料功能化集成与实际应用场景适配不足的问题，通过引入功能化生物分子、异质力学单元和界面调控结构，并结合水凝胶力学载体设计，构建了多类面向实际应用的功能化软物质材料体系。相关材料在细胞力学调控、组织修复、湿态粘附、柔性传感、保水界面和低摩擦涂层等方面展现出良好应用潜力，初步建立了从分子设计到力学材料结构设计到功能应用验证的研究路径（Nat. Commun. 2026,17, 2430; Nat. Mater. 2026, 25, 1199–1208; Nat. Commun. 2025, 16, 3633; Nat. Commun. 2024, 15, 10569; Nat. Commun. 2021, 12, 7156; Natl. Sci. Rev. 2022, 9(7), nwab147; PNAS, 2021, 118 (37), e2110961118;Adv. Funct. Mater., 2026, e76135）。

代表性论文：

(1) Wei Sun, Xiaoxiao Sun, Junsheng Zhang, Lin Wu, Juan Wang, Wei Wang^*, Yi Cao^* & Bin Xue^*, Hierarchical picot-fiber hydrogel coating with ultralow friction and high wear resistance, Nature Communications, 2026, 17, 2430

(2) Mengjiao Pei, Tian Gao, Li Liu, Wenlong Li, Haotian Long, Yifei Luo, Zhaogang Teng, Hangyuan Cui, Xiang Li, Qinyong Dai, Kailu Shi, Lesheng Qiao, Baocheng Peng, Qianye Xing, Manhua Wen, Mengtao Han, Zhenhua Wan, Yun Li^*, Bin Xue^*, Yi Cao, Yi Shi^*, Qing Wan^*, Xiaodong Chen^* & Changjin Wan^*, An iontronic reservoir for highly robust neuromorphic prosthesis, Nature Materials, 2026, 25, 1199–1208

(3) Tingting Ma, Wei Sun, Meng Qin, Shen Yin, Yiran Li*, Yi Cao*, Bin Xue*, Wei Wang*, Mechanically Induced Adaptive Self-Growing Protein Hydrogel, Advanced Materials, 2026, e23636

(4) Hui Yuan, Zhongyuan Yang, Chengqian Yuan, Sudha Shankar, Aviad Levin, Tiancheng Lv, Zihan Wang, Wei Sun, Jadon Sitton, Pierre-Andre Cazade, Yoav Dan, Yiming Tang, Lihi Adler-Abramovich, Yi Cao, Sigal Rencus-Lazar, Damien Thompson, Dmitry Kurouski, Tuomas P. J. Knowles, Linda J. W. Shimon, Guanghong Wei^*, Bin Xue^*, Rusen Yang^* & Ehud Gazit^*, Formation of S- and Z-twist supramolecular micro-ropes by peptide stereoisomers, Nature Communications, 2026, 17, 4424

(5) Bin Xue^#*, Xu Han^#, Haoqi Zhu^#, Qingtai Li, Yu Zhang, Ming Bai, Ying Li, Yiran Li, Meng Qin, Tasuku Nakajima, Wei Wang^*, Jian Ping Gong^* & Yi Cao^*. Hydrogels with prestressed tensegrity structures, Nature Communications, 2025, 16, 3637

(6) Bin Xue^#*, Zhengyu Xu^#, Lan Li^#, Kaiqiang Guo, Jing Mi, Haipeng Wu, Yiran Li, Chunmei Xie, Jing Jin, Juan Xu, Chunping Jiang, Xiaosong Gu, Meng Qin, Qing Jian^*, Yi Cao^* & Wei Wang^*. Hydrogels with programmed spatiotemporal mechanical cues for stem cell-assisted bone regeneration, Nature Communications, 2025, 16, 3633 (高被引)

(7) Yuanqi Cheng, Tianjian Wang, Haoqi Zhu, Xueli Hu, Jing Mi, Lan Li, Yu Zhang, Jiapeng Yang, Liang Dong, Ying Li, Wenxu Sun, Xiaomei Lu, Wei Wang^*, Yi Cao^* & Bin Xue^*. Molecular Engineering of Amino Acid Crystals with Enhanced Piezoelectric Performance for Biodegradable Sensors. Angewandte Chemie International Edition, 2025, 64(15), e202500334

(8) Ming Bai, Yanru Chen, Liyang Zhu, Ying Li, Tingting Ma, Yiran Li, Meng Qin, Wei Wang^*, Yi Cao^*. Bin Xue^*, Bioinspired adaptive lipid-integrated bilayer coating for enhancing dynamic water retention in hydrogel-based flexible sensors, Nature Communications, 2024, 15, 10569

(9) Zhengyu Xu, Jiajun Lu, Di Lu, Yiran Li, Hai Lei, Bin Chen, Wenfei Li, Bin Xue^*, Yi Cao^*, Wei Wang^*. Rapidly damping hydrogels engineered through molecular friction, Nature Communications, 2024, 15, 4895

(10) Bin Xue^#, Zoobia Bashir^#, Yachong Guo, Wenting Yu, Wenxu Sun, Yiran Li, Yiyang Zhang, Meng Qin, Wei Wang^* and Yi Cao^*. Strong, tough, rapid-recovery, and fatigue-resistant hydrogels made of picot peptide fibres, Nature Communications, 2023, 2583. (高被引)

(11) Yuanqi Cheng^#, Juan Xu^#, Lan Li, Pingqiang Cai, Ying Li, Qing Jiang^*, Wei Wang^*, Yi Cao^*, and Bin Xue^*, Boosting the Piezoelectric Sensitivity of Amino Acid Crystals by Mechanical Annealing for the Engineering of Fully Degradable Force Sensors, Advanced Science, 2023, 10(11), 2207269

(12) Bin Xue^#, Hui Sheng^#, Yongqiang Li, Lan Li, Weishuai Di, Zhengyu Xu, Linjie Ma, Xin Wang, Haoting Jiang, Meng Qin, Zhibo Yan, Qing Jiang, Jun-Ming Liu, Wei Wang^*, Yi Cao^*, Stretchable and self-healable hydrogel artificial skin, National Science Review, 2022, 9(7), nwab147.

(13) Guangxiao He, Hai Lei, Wenxu Sun, Jie Gu, Wenting Yu, Di Zhang, Huiyan Chen, Ying Li, Meng Qin, Bin Xue^*, Wei Wang^*, and Yi Cao^*, Strong and Reversible Covalent Double Network Hydrogel Based on Force-coupled Enzymatic Reactions, Angewandte Chemie International Edition, 2022, e202201765 (hot paper)

(14) Bin Xue^#, Jie Gu^#, Lan Li^#, Wenting Yu, Sheng Yin, Meng Qin, Qing Jiang^*, Wei Wang^* and Yi Cao^*, Hydrogel tapes for fault-tolerant strong wet adhesion. Nature Communications, 2021, 12: 7156. (高被引)

(15) Bin Xue^#, Dehua Tang^#, Xin Wu, Zhengyu Xu, Jie Gu, Yueying Han, Zhenshu Zhu, Meng Qin, Xiaoping Zou, Wei Wang, and Yi Cao^*. Engineering hydrogels with homogeneous mechanical properties for controlling stem cell lineage specification, PNAS, 2021, 118 (37): e2110961118.